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Proceedings Paper

Biodistribution, pharmacokinetic, and in-vivo fluorescence spectroscopic studies of photosensitizers
Author(s): Johan Moan; Qian Peng; Vladimir Iani; Li Wei Ma; Richard W. Horobin; Kristian Berg; Magne Kongshaug; Jahn M. Nesland
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Paper Abstract

Some key data concerning the pharmacokinetics of PCT photosensitizers are reviewed. The following topics are discussed: The binding of photosensitizers to serum proteins, and the significance of LDL binding for tumor localization, the distribution of sensitizers among different tissue compartments and the significance of extracellular proteins and other stromal elements, such as macrophages, low tumor pH, leaky vasculature and poor lymphatic drainage for tumor selectivity of drugs, the retention and excretion of sensitizers, and intracellular pharmacokinetics. Furthermore, the usefulness of fluorescence measurements in the study of sensitizer pharmacokinetics is briefly discussed. A key observation is that 1O2 has a short radius of action. Since practically all PCT sensitizers act via the 1O2 pathway, only targets with significant sensitizer concentrations can be damaged. A given number of 1O2 entities generated in different organelles (mitochondria, lysosomes, plasma membrane, etc.) may lead to widely different effects with respect to cell inactivation. Similarly, sensitizers localizing in different compartments of tissues may have different photosensitizing efficiencies even under conditions of a similar 1O2 yield.

Paper Details

Date Published: 31 January 1996
PDF: 17 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.231008
Show Author Affiliations
Johan Moan, Institute for Cancer Research (Norway)
Qian Peng, Institute for Cancer Research (Norway)
Vladimir Iani, Institute for Cancer Research (Norway)
Li Wei Ma, Institute for Cancer Research (Norway)
Richard W. Horobin, Sheffield Univ. (United Kingdom)
Kristian Berg, Institute for Cancer Research (Norway)
Magne Kongshaug, Institute for Cancer Research (Norway)
Jahn M. Nesland, Institute for Cancer Research (Norway)

Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)

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