Topically applied ALA-PDT for human nodular basal cell carcinoma has encountered some problems, one of which is that the concentration of ALA-induced PpIX is in some cases too low to sensitize complete tumor destruction. Our present study, by means of an optical-fiber based point monitoring system in situ, has shown that the fluorescence intensity of PpIX was significantly higher in the normal skin of nude mice after topical application of ALA and desferrioxamine (DF) or in combination with DMSO than that of ALA alone or ALA plus DMSO. These data indicate that DF has an effect on enhancing the production of ALA- induced PpIX in the mouse skin. Thus, there may clinically be advantages of using ALA and DF over ALA alone in PDT of superficial skin lesions.

Date Published: 31 January 1996
PDF: 7 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230941

Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)