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Proceedings Paper

Regional variations of skin blood flow response to histamine: evaluation by spectrophotometry and laser Doppler flowmetry
Author(s): Ethel Tur; Guy Aviram; D. Zeltser; Sarah Brenner; Howard I. Maibach
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Paper Abstract

To study inherent differences in skin function related to regional variation, we tested the hypothesis that different reactivities of small blood vessels via their direct and indirect activation by histamine play an important role in the observed regional variation of processes. Histamine was administered to three cutaneous regions in 20 volunteers, and the induced response was quantified utilizing spectrophotometry and laser Doppler flowmetry. The back exhibited the greatest response, followed by the forearm and ankle in decreasing order of responsiveness. We suggest that the intensity of the wheal and flare response may partly be related to the local reactivity of the blood vessels once the histamine actually reached them, and to their indirect dilatation via the axonal reflex. These blood vessel response observations may provide initial insight into inherent functional differences influencing cutaneous manifestations of endogenous and exogenous diseases.

Paper Details

Date Published: 19 January 1996
PDF: 5 pages
Proc. SPIE 2623, Medical Applications of Lasers III, (19 January 1996); doi: 10.1117/12.230316
Show Author Affiliations
Ethel Tur, Tel Aviv Medical Ctr. (Israel)
Guy Aviram, Tel Aviv Medical Ctr. (Israel)
D. Zeltser, Tel Aviv Medical Ctr. (Israel)
Sarah Brenner, Tel Aviv Medical Ctr. (Israel)
Howard I. Maibach, Univ. of California/San Francisco (United States)

Published in SPIE Proceedings Vol. 2623:
Medical Applications of Lasers III
Stephen G. Bown; Herbert J. Geschwind M.D.; Raimund Hibst; Frederic Laffitte; Giulio Maira; Roberto Pini; Hans-Dieter Reidenbach; Hans H. Scherer M.D.; Pasquale Spinelli, Editor(s)

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