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Proceedings Paper

A novel fiber-free technique for brain activity imaging in multiple freely behaving mice
Author(s): Shigenori Inagaki; Masakazu Agetsuma; Takeharu Nagai
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Paper Abstract

Brain functions and related psychiatric disorders have been investigated by recording electrophysiological field potential. When recording it, a conventional method requires fiber-based apparatus connected to the brain, which however hampers the simultaneous measurement in multiple animals (e.g. by a tangle of fibers). Here, we propose a fiber-free recording technique in conjunction with a ratiometric bioluminescent voltage indicator. Our method allows investigation of electrophysiological filed potential dynamics in multiple freely behaving animals simultaneously over a long time period. Therefore, this fiber-free technique opens up the way to investigate a new mechanism of brain function that governs social behaviors and animal-to-animal interaction.

Paper Details

Date Published: 14 February 2018
PDF: 4 pages
Proc. SPIE 10482, Optogenetics and Optical Manipulation 2018, 104820I (14 February 2018); doi: 10.1117/12.2302396
Show Author Affiliations
Shigenori Inagaki, Osaka Univ. (Japan)
Masakazu Agetsuma, Osaka Univ. (Japan)
National Institute for Physiological Sciences (Japan)
Takeharu Nagai, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 10482:
Optogenetics and Optical Manipulation 2018
Samarendra K. Mohanty; Nitish V. Thakor; E. Duco Jansen, Editor(s)

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