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Proceedings Paper

Real-time monitoring of the cell physiological and pathological processes using computer-aided phase microscope
Author(s): Irina A. Vasilenko; Vladimir Shabalin; Vladimir P. Tychinsky; Georgy E. Kufal; A. Konradov; O. I. Slinchenko
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Paper Abstract

Living cells investigation and cell response to external factors are of great interest for practical medicine and biology. The main advantages of computer aided phase microscope (CPM) Cytoscan which permits us to observe the cell surface and internal structure consists in superresolution and the possibility of the dynamic processes registering. We attempt to characterize some aspects of the morphofunctional status of human lymphocytes determining the dynamics of the selected points in normal or pathological cells. To evaluate the lymphocyte homeostasis donors and persons of autoimmune diseases were analyzed and the changes of optical and geometrical cell parameters registered by CPM Cytoscan. The dynamic process registration allowed us to perform the real-time quantitative analysis of the living lymphocyte activity in norm and pathology.

Paper Details

Date Published: 15 January 1996
PDF: 5 pages
Proc. SPIE 2628, Optical and Imaging Techniques for Biomonitoring, (15 January 1996); doi: 10.1117/12.230006
Show Author Affiliations
Irina A. Vasilenko, Institute of Rheumatology (Russia)
Vladimir Shabalin, Institute of Rheumatology (Russia)
Vladimir P. Tychinsky, Moscow Institute for Radioengineering, (Russia)
Georgy E. Kufal, Moscow Institute for Radioengineering, (Russia)
A. Konradov, Institute of Chemical Physics (Russia)
O. I. Slinchenko, Institute of Rheumatology (Russia)

Published in SPIE Proceedings Vol. 2628:
Optical and Imaging Techniques for Biomonitoring
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D.; Michel Robert-Nicoud; Herbert Schneckenburger, Editor(s)

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