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Proceedings Paper

Subcellular photodynamic action sites of sulfonated aluminum phthalocyanines in a human melanoma cell line
Author(s): Qian Peng; Jahn M. Nesland; Kari Madslien; Havard E. Danielsen; Johan Moan
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Paper Abstract

By means of scanning and transmission electron microscopy the subcellular target sites of photodynamic therapy (PDT) with derivatives of sulfonated aluminum phthalocyanine (AlPcS1, AlPcS2, AlPcS3, and AlPcS4) were studied in a human melanoma LOX cell line. It was found that PDT with AlPcS1 or AlPcS2 damaged mainly the biomembraneous system of the cells, such as cytoplasmic membrane, mitochondria, endoplasmic reticulum, etc., while AlPcS3- or AlPcS4- induced PDT largely destroyed the lysosomes. However, none of the AlPcSns led to nuclear damage at an early stage after PDT. The subcellular photodynamic targets of the derivatives of AlPcSn are related to the subcellular localization pattern of the dye in the LOX cells.

Paper Details

Date Published: 15 January 1996
PDF: 12 pages
Proc. SPIE 2628, Optical and Imaging Techniques for Biomonitoring, (15 January 1996); doi: 10.1117/12.229977
Show Author Affiliations
Qian Peng, Norwegian Radium Hospital (Norway)
Jahn M. Nesland, Norwegian Radium Hospital (Norway)
Kari Madslien, Norwegian Radium Hospital (Norway)
Havard E. Danielsen, Norwegian Radium Hospital (Norway)
Johan Moan, Norwegian Radium Hospital (Norway)

Published in SPIE Proceedings Vol. 2628:
Optical and Imaging Techniques for Biomonitoring
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D.; Michel Robert-Nicoud; Herbert Schneckenburger, Editor(s)

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