Preclinical studies of a new light emitting diode light source suitable for photodynamic therapy at 650 nm are described. The light source is found to produce effective cell kill using the colo26 cell line and the photosensitizer m-THPC. The performance of the LED source for PDT in tissue is evaluated in comparison with a copper vapor pumped dye laser by measuring depth of necrosis obtained in normal rat liver. Similar depths of necrosis are obtained. It is concluded that the device shows promise as an alternative light source for photodynamic therapy with m-THPC.

Date Published: 8 January 1996
PDF: 7 pages
Proc. SPIE 2629, Biomedical Optoelectronics in Clinical Chemistry and Biotechnology, (8 January 1996); doi: 10.1117/12.229531

Published in SPIE Proceedings Vol. 2629:
Biomedical Optoelectronics in Clinical Chemistry and Biotechnology
Stefan Andersson-Engels; Mario Corti; Ivan Kertesz; Norbert Kroo; Heinz P. Weber; Terence A. King; Riccardo Pratesi; Stefan Seeger, Editor(s)