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Proceedings Paper

Transfer learning with convolutional neural networks for lesion classification on clinical breast tomosynthesis
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Paper Abstract

With growing adoption of digital breast tomosynthesis (DBT) in breast cancer screening protocols, it is important to compare the performance of computer-aided diagnosis (CAD) in the diagnosis of breast lesions on DBT images compared to conventional full-field digital mammography (FFDM). In this study, we retrospectively collected FFDM and DBT images of 78 lesions from 76 patients, each containing lesions that were biopsy-proven as either malignant or benign. A square region of interest (ROI) was placed to fully cover the lesion on each FFDM, DBT synthesized 2D images, and DBT key slice images in the cranial-caudal (CC) and mediolateral-oblique (MLO) views. Features were extracted on each ROI using a pre-trained convolutional neural network (CNN). These features were then input to a support vector machine (SVM) classifier, and area under the ROC curve (AUC) was used as the figure of merit. We found that in both the CC view and MLO view, the synthesized 2D image performed best (AUC = 0.814, AUC = 0.881 respectively) in the task of lesion characterization. Small database size was a key limitation in this study, and could lead to overfitting in the application of the SVM classifier. In future work, we plan to expand this dataset and to explore more robust deep learning methodology such as fine-tuning.

Paper Details

Date Published: 27 February 2018
PDF: 6 pages
Proc. SPIE 10575, Medical Imaging 2018: Computer-Aided Diagnosis, 105750T (27 February 2018); doi: 10.1117/12.2294973
Show Author Affiliations
Kayla R. Mendel, The Univ. of Chicago (United States)
Hui Li, The Univ. of Chicago (United States)
Deepa Sheth, The Univ. of Chicago (United States)
Maryellen L. Giger, The Univ. of Chicago (United States)

Published in SPIE Proceedings Vol. 10575:
Medical Imaging 2018: Computer-Aided Diagnosis
Nicholas Petrick; Kensaku Mori, Editor(s)

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