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Proceedings Paper

Endoscopic photodynamic therapy of tumors using gold vapor laser
Author(s): Yury P. Kuvshinov; Boris K. Poddubny; Andrei F. Mironov; Igor V. Ponomarev; V. V. Shental; Yu. E. Vaganov; T. T. Kondratjeva; E. V. Trofimova
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Paper Abstract

Compact sealed-off gold vapor laser (GVL) with 2 W average power and 628 nm wavelength was used for endoscopic photodynamic therapy in 20 patients with different tumors in respiratory system and upper gastrointestinal tract. Russian-made hematoporphyrin derivative (Hpd) `Photohem' was used as a photosensitizer. It was given intravenously at a dose of 2 - 2.5 mg/kg body weight 48 hours prior to tumor illumination with 628 nm light from GVL. Intermittent irradiation with GVL was done through flexible endoscope always under local anaesthesia at a power of 200 - 400 mW/sm2 and a dose of 150 - 400 J/sm2. 80% patients showed complete or partial response depending on stage of tumor. In cases of early gastric cancer all patients had complete remission with repeated negative biopsies. No major complication occurred.

Paper Details

Date Published: 8 January 1996
PDF: 4 pages
Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); doi: 10.1117/12.229488
Show Author Affiliations
Yury P. Kuvshinov, N.N. Blokhin Cancer Research Ctr. (Russia)
Boris K. Poddubny, N.N. Blokhin Cancer Research Ctr. (Russia)
Andrei F. Mironov, Lomonosov State Academy of Fine Chemical Technology (Russia)
Igor V. Ponomarev, P. N. Lebedev Physical Institute (Russia)
V. V. Shental, N.N. Blokhin Cancer Research Ctr. (Russia)
Yu. E. Vaganov, N.N. Blokhin Cancer Research Ctr. (Russia)
T. T. Kondratjeva, N.N. Blokhin Cancer Research Ctr. (Russia)
E. V. Trofimova, N.N. Blokhin Cancer Research Ctr. (Russia)

Published in SPIE Proceedings Vol. 2728:
CIS Selected Papers: Laser Use in Oncology
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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