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Proceedings Paper

Pharmacokinetics of 2,4-di(alpha-methoxyethyl)deuteroporphyrin-IX (dimehin) and its complex with chitosan in mice with tumors
Author(s): Andrei V. Ivanov; A. T. Gradyushko; V. P. Laptev; N. G. Panferova; V. P. Varlamov; B. A. Klyashchitsky; Andrei V. Reshetnickov; Gelii V. Ponomarev
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Paper Abstract

The kinetics of photosensitizer distribution and elimination have been studied using fluorescent methods in organs and tumors of A/Snell mice with embriocarcinoma inoculated into their thigh muscles for the porphyrin compound 2,4-di((alpha) -methoxyethyl)deuteroporphyrin-- IX (DMH, `Dimehin') and its complex with polysaccharide chitosan. DMH fluorescence differs in samples of liver and faeces which follows from the spectra comparison. DMH is metabolizable upon passing through liver into a form eliminated by the gastrointestinal tract as our pharmacokinetic data have shown. DMH has been found to be a short-term highly photodynamically efficient photosensitizer judging by combined analysis of our toxicological, pharmacokinetic and photodynamic research data. DMH-chitosan uptake and distribution studies have shown the complex's long-term persistence in blood circulation, high level accumulation in spleen and lungs, whereas there was no complex registered in tumors and other tissues following i.v. administration.

Paper Details

Date Published: 8 January 1996
PDF: 13 pages
Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); doi: 10.1117/12.229486
Show Author Affiliations
Andrei V. Ivanov, N.N. Blokhin Cancer Research Ctr. (Russia)
A. T. Gradyushko, N.N. Blokhin Cancer Research Ctr. (Russia)
V. P. Laptev, N.N. Blokhin Cancer Research Ctr. (Russia)
N. G. Panferova, N.N. Blokhin Cancer Research Ctr. (Russia)
V. P. Varlamov, Ctr. of Bioengineering (Russia)
B. A. Klyashchitsky, Institute of Biomedical Chemistry (Russia)
Andrei V. Reshetnickov, Institute of Biomedical Chemistry (Russia)
Gelii V. Ponomarev, Institute of Biomedical Chemistry (Russia)

Published in SPIE Proceedings Vol. 2728:
CIS Selected Papers: Laser Use in Oncology
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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