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Proceedings Paper

3D tissue mimicking biophantoms for ultrasound imaging: bioprinting and image analysis
Author(s): Shekoofeh Azizi; Sharareh Bayat; Ajay Rajaram; Emran M. A. Anas; Tamer Mohamed; Konrad Walus; Purang Abolmaesumi; Parvin Mousavi
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Paper Abstract

Tissue-mimicking phantoms can be used to study various diagnostic imaging techniques and image-guided therapeutic interventions. Bioprinting enables the incorporation of live cells into printed phantoms. Some advantages of bioprinted phantoms include their close similarity to in vivo condition and change in phantom composition with time as the cells proliferate and secrete the extra cellular matrix components. In this study, we 3D-print alginate to form three different types of phantoms; those containing human vascular smooth muscle cells, human liver cancer cells, and no cells, each representing benign tissue, cancer tissue, and controls, respectively. The phantoms are imaged with a clinical ultrasound scanner and Temporal Enhanced Ultrasound (TeUS) data is collected. The comparison of the power spectrum of TeUS depicts separation among the three phantom types.

Paper Details

Date Published: 13 March 2018
PDF: 7 pages
Proc. SPIE 10576, Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling, 105761T (13 March 2018); doi: 10.1117/12.2293930
Show Author Affiliations
Shekoofeh Azizi, The Univ. of British Columbia (Canada)
Sharareh Bayat, The Univ. of British Columbia (Canada)
Ajay Rajaram, Queen's Univ. (Canada)
Emran M. A. Anas, Johns Hopkins Univ. (United States)
Tamer Mohamed, Aspect Biosystems Ltd. (Canada)
Konrad Walus, Aspect Biosystems Ltd. (Canada)
Purang Abolmaesumi, The Univ. of British Columbia (Canada)
Parvin Mousavi, Queen's Univ. (Canada)

Published in SPIE Proceedings Vol. 10576:
Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling
Baowei Fei; Robert J. Webster III, Editor(s)

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