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Proceedings Paper

Robustness of radiomic breast features of benign lesions and luminal A cancers across MR magnet strengths
Author(s): Heather M. Whitney; Karen Drukker; Alexandra Edwards; John Papaioannou; Maryellen L. Giger
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Paper Abstract

Radiomics features extracted from breast lesion images have shown potential in diagnosis and prognosis of breast cancer. As clinical institutions transition from 1.5 T to 3.0 T magnetic resonance imaging (MRI), it is helpful to identify robust features across these field strengths. In this study, dynamic contrast-enhanced MR images were acquired retrospectively under IRB/HIPAA compliance, yielding 738 cases: 241 and 124 benign lesions imaged at 1.5 T and 3.0 T and 231 and 142 luminal A cancers imaged at 1.5 T and 3.0 T, respectively. Lesions were segmented using a fuzzy C-means method. Extracted radiomic values for each group of lesions by cancer status and field strength of acquisition were compared using a Kolmogorov-Smirnov test for the null hypothesis that two groups being compared came from the same distribution, with p-values being corrected for multiple comparisons by the Holm-Bonferroni method. Two shape features, one texture feature, and three enhancement variance kinetics features were found to be potentially robust. All potentially robust features had areas under the receiver operating characteristic curve (AUC) statistically greater than 0.5 in the task of distinguishing between lesion types (range of means 0.57-0.78). The significant difference in voxel size between field strength of acquisition limits the ability to affirm more features as robust or not robust according to field strength alone, and inhomogeneities in static field strength and radiofrequency field could also have affected the assessment of kinetic curve features as robust or not. Vendor-specific image scaling could have also been a factor. These findings will contribute to the development of radiomic signatures that use features identified as robust across field strength.

Paper Details

Date Published: 27 February 2018
PDF: 8 pages
Proc. SPIE 10575, Medical Imaging 2018: Computer-Aided Diagnosis, 105750A (27 February 2018); doi: 10.1117/12.2293764
Show Author Affiliations
Heather M. Whitney, The Univ. of Chicago (United States)
Wheaton College (United States)
Karen Drukker, The Univ. of Chicago (United States)
Alexandra Edwards, The Univ. of Chicago (United States)
John Papaioannou, The Univ. of Chicago (United States)
Maryellen L. Giger, The Univ. of Chicago (United States)

Published in SPIE Proceedings Vol. 10575:
Medical Imaging 2018: Computer-Aided Diagnosis
Nicholas Petrick; Kensaku Mori, Editor(s)

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