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Proceedings Paper

Splenomegaly segmentation using global convolutional kernels and conditional generative adversarial networks
Author(s): Yuankai Huo; Zhoubing Xu; Shunxing Bao; Camilo Bermudez; Andrew J. Plassard; Jiaqi Liu; Yuang Yao; Albert Assad; Richard G. Abramson; Bennett A. Landman
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Paper Abstract

Spleen volume estimation using automated image segmentation technique may be used to detect splenomegaly (abnormally enlarged spleen) on Magnetic Resonance Imaging (MRI) scans. In recent years, Deep Convolutional Neural Networks (DCNN) segmentation methods have demonstrated advantages for abdominal organ segmentation. However, variations in both size and shape of the spleen on MRI images may result in large false positive and false negative labeling when deploying DCNN based methods. In this paper, we propose the Splenomegaly Segmentation Network (SSNet) to address spatial variations when segmenting extraordinarily large spleens. SSNet was designed based on the framework of image-to-image conditional generative adversarial networks (cGAN). Specifically, the Global Convolutional Network (GCN) was used as the generator to reduce false negatives, while the Markovian discriminator (PatchGAN) was used to alleviate false positives. A cohort of clinically acquired 3D MRI scans (both T1 weighted and T2 weighted) from patients with splenomegaly were used to train and test the networks. The experimental results demonstrated that a mean Dice coefficient of 0.9260 and a median Dice coefficient of 0.9262 using SSNet on independently tested MRI volumes of patients with splenomegaly.

Paper Details

Date Published: 2 March 2018
PDF: 7 pages
Proc. SPIE 10574, Medical Imaging 2018: Image Processing, 1057409 (2 March 2018); doi: 10.1117/12.2293406
Show Author Affiliations
Yuankai Huo, Vanderbilt Univ. (United States)
Zhoubing Xu, Vanderbilt Univ. (United States)
Shunxing Bao, Vanderbilt Univ. (United States)
Camilo Bermudez, Vanderbilt Univ. (United States)
Andrew J. Plassard, Vanderbilt Univ. (United States)
Jiaqi Liu, Vanderbilt Univ. (United States)
Yuang Yao, Vanderbilt Univ. (United States)
Albert Assad, Incyte Corp. (United States)
Richard G. Abramson, Vanderbilt Univ. (United States)
Bennett A. Landman, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 10574:
Medical Imaging 2018: Image Processing
Elsa D. Angelini; Bennett A. Landman, Editor(s)

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