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Proceedings Paper

Ex-vivo mice mammary glands characterization using energy-dispersive x-ray diffraction and spacially resolved CdZnTe detectors
Author(s): Vera Feldman; Joachim Tabary; Caroline Paulus; Jean-Louis Hazemann; Odile Filhol; Isabelle Vilgrain; Loïck Verger
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Paper Abstract

False-positive mammography results in breast cancer diagnosis can lead to unnecessary biopsies which are invasive and time-consuming. X-Ray Diffraction (XRD) has the potential of providing diagnosis-relevant information and thus can be used after a mammography to verify its results and possibly avoid needless biopsy. We present an energy-dispersive X-Ray Diffraction (EDXRD) system and data analysis method which allowed us to characterize healthy and cancerous mice mammary glands ex-vivo. Our technique showed decent glad localization along the z-axis as well as scatter signatures coherent with ones previously described in literature. We used an in-house spatially resolved CdZnTe detector, and a subpixelation technique which enhances spatial resolution. Acquisition time and dose delivered are to be optimized yet, however our results demonstrate the potential of EDXRD systems for depth-resolved breast imaging. Different geometries and processing algorithms are currently being investigated in the development of a future EDXRD clinical system for breast cancer diagnosis.

Paper Details

Date Published: 9 March 2018
PDF: 8 pages
Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105732B (9 March 2018); doi: 10.1117/12.2292866
Show Author Affiliations
Vera Feldman, Univ. Grenoble Alpes (France)
CEA, LETI, MINATEC (France)
Joachim Tabary, Univ. Grenoble Alpes (France)
CEA, LETI, MINATEC (France)
Caroline Paulus, Univ. Grenoble Alpes (France)
CEA, LETI, MINATEC (France)
Jean-Louis Hazemann, Univ. Grenoble Alpes (France)
Institut NEEL, CNRS (France)
Odile Filhol, Univ. Grenoble Alpes (France)
INSERM (France)
CEA, Biosciences and Biotechnology Institute of Grenoble, Biology of Cancer and Infection (France)
Isabelle Vilgrain, Univ. Grenoble Alpes (France)
INSERM (France)
CEA, Biosciences and Biotechnology Institute of Grenoble, Biology of Cancer and Infection (France)
Loïck Verger, Univ. Grenoble Alpes (France)
CEA, LETI, MINATEC (France)


Published in SPIE Proceedings Vol. 10573:
Medical Imaging 2018: Physics of Medical Imaging
Joseph Y. Lo; Taly Gilat Schmidt; Guang-Hong Chen, Editor(s)

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