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Proceedings Paper

Quantifying changes in lens biomechanical properties due to cold cataract with optical coherence elastography
Author(s): Hongqiu Zhang; Chen Wu; Manmohan Singh; Kirill V. Larin
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Paper Abstract

Cataract is the most prevalent cause of visual impairment worldwide. Cataracts can be formed due to trauma, radiation, drug abuse, or low temperatures. Thus, early detection of cataract can be immensely helpful for preserving visual acuity by ensuring that the appropriate therapeutic procedures are performed at earlier stages of disease onset and progression. In this work, we utilized a phase-sensitive optical coherence elastography (OCE) system to quantify changes in biomechanical properties of porcine lenses in vitro with induced cold cataracts. The results show significant increase in lens Young’s modulus due to formation of the cold cataract (from ~ 35 kPa to ~60 kPa). These results show that OCE can assess lenticular biomechanical properties and may be useful for detecting and, potentially, characterizing cataracts.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104741Y (19 February 2018); doi: 10.1117/12.2291285
Show Author Affiliations
Hongqiu Zhang, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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