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Proceedings Paper

Systematic in-vivo investigation of intrinsic optical signals in the photoreceptor outer segment (Conference Presentation)
Author(s): Clara Pfäffle; Dierck Hillmann; Hendrik Spahr; Bastian Kabuth; Gereon M. Hüttmann

Paper Abstract

Full-field-swept-source optical coherence tomography is capable of detecting small morphological changes in the living human eye below sub-wavelength range by evaluating the phases. This is used to obtain intrinsic optical signals originating in the photoreceptor outer segment, spatially resolved to single photoreceptors. These were measured ex-vivo in explanted porcine retina as well as in the living human eye. The obtained signals are related to an increase of the optical path length of the outer segments. However, they give no hint wether they are caused by an actual physical expansion of the outer segments or by a changes in the index of refraction. Therefore, systematical measurements were carried out to determine the physical nature and biochemical source of the observed effects.

Paper Details

Date Published: 14 March 2018
Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104740Y (14 March 2018); doi: 10.1117/12.2289883
Show Author Affiliations
Clara Pfäffle, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Dierck Hillmann, Thorlabs GmbH (Germany)
Hendrik Spahr, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Bastian Kabuth, Institut für Biomedizinische Optik, Univ. zu Lübeck (Germany)
Gereon M. Hüttmann, Institut für Biomedizinische Optik, Univ. zu Lübeck (Germany)
Medizinisches Laserzentrum Lübeck GmbH (Germany)
Airway Research Ctr. North, Deutsches Zentrum Für Lungenforschung (Germany)

Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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