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Proceedings Paper

In-vivo detection of the skin dermo-epidermal junction by ultrahigh resolution optical coherence tomography (Conference Presentation)
Author(s): Niels M. Israelsen; Michael Maria; Mette Mogensen; Sophie Bojesen M.D.; Mikkel Jensen; Merete Haedersdal M.D.; Adrian Podoleanu; Ole Bang

Paper Abstract

The human skin is comprised by two layers; epidermis and dermis, separated by the dermo-epidermal junction (DEJ). The relevance of depicting DEJ and measurement of the epidermal thickness (ET) is e.g. seen for superficial skin cancers where delineation of DEJ is of prime prognostic importance. Another example is diagnosis of psoriasis where a thickened epidermis and a ridged DEJ is a hallmark. Histopathological examination of biopsied tissue is traditionally performed to trace DEJ and measure ET. An efficient and precise method to locate DEJ and measure ET is optical coherence tomography (OCT) which is an in vivo and non-invasive technique. Because of significant changes in the refractive index across the DEJ, it is generally easily resolvable with OCT. However at certain body locations, such as the cheek and in regions of glabrous skin, it is difficult to visualize DEJ since refractive index changes are small. We study the significance of ultrahigh resolution OCT combined with a shadow compensation algorithm in locating the DEJ of the cheek and the palm of the hand of ten healthy volunteers. For the study we use a home-built ultrahigh resolution OCT system and a commercially available OCT system designed for dermatology diagnostic. With this comparative study we conclude on the signal statistics of both dermis and epidermis for the two OCT systems and how the differences of these affect the delineation of DEJ. We finally conclude on the significance of ultrahigh resolution OCT in detecting DEJ and measuring ET.

Paper Details

Date Published: 14 March 2018
Proc. SPIE 10467, Photonics in Dermatology and Plastic Surgery 2018, 1046705 (14 March 2018); doi: 10.1117/12.2289880
Show Author Affiliations
Niels M. Israelsen, Technical Univ. of Denmark (Denmark)
Michael Maria, NKT Photonics Inc. (Denmark)
Univ. of Kent (United Kingdom)
Mette Mogensen, Bispebjerg Hospital (Denmark)
Sophie Bojesen M.D., Bispebjerg Hospital (Denmark)
Mikkel Jensen, Technical Univ. of Denmark (Denmark)
Merete Haedersdal M.D., Bispebjerg Hospital (Denmark)
Adrian Podoleanu, Univ. of Kent (United Kingdom)
Ole Bang, Technical Univ. of Denmark (Denmark)
NKT Photonics (Denmark)

Published in SPIE Proceedings Vol. 10467:
Photonics in Dermatology and Plastic Surgery 2018
Bernard Choi; Haishan Zeng, Editor(s)

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