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Proceedings Paper

Light-activated microbubbles around gold nanorods for photoacoustic microsurgery
Author(s): Lucia Cavigli; Sonia Centi; Sarah Lai; Claudia Borri; Filippo Micheletti; Paolo Tortoli; Ilaria Panettieri; Ingolf Streit; Francesca Rossi; Fulvio Ratto; Roberto Pini
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Paper Abstract

The increasing interest around imaging and microsurgery techniques based on the photoacoustic effect has boosted active research into the development of exogenous contrast agents that may enhance the potential of this innovative approach.

In this context, plasmonic particles as gold nanorods are achieving resounding interest, owing to their efficiency of photothermal conversion, intense optical absorbance in the near infrared region, inertness in the body and convenience for conjugation with ligands of molecular targets.

On the other hand, the photoinstability of plasmonic particles remains a remarkable obstacle. In particular, gold nanorods easily reshape into nanospheres and so lose their optical absorbance in the near infrared region, under exposure to few-ns-long laser pulses. This issue is attracting much attention and stimulating ad-hoc solutions, such as the addition of rigid shells and the optimization of multiple parameters.

In this contribution, we focus on the influence of the shape of gold nanorods on their photothermal behavior and photostability. We describe the photothermal process in the gold nanorods by modeling their optical absorption and consequent temperature dynamics as a function of their aspect ratio (length / diameter).

Our results suggest that increasing the aspect ratio does probably not limit the photostability of gold nanorods, while shifting the plasmonic peak towards wavelengths around 1100 nm, which hold more technological interest.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104942D (19 February 2018); doi: 10.1117/12.2289875
Show Author Affiliations
Lucia Cavigli, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Sonia Centi, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Sarah Lai, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Claudia Borri, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Filippo Micheletti, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Paolo Tortoli, Univ. degli Studi di Firenze (Italy)
Ilaria Panettieri, Politecnico di Torino (Italy)
Ingolf Streit, Asclepion Laser Technologies GmbH (Germany)
Francesca Rossi, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Fulvio Ratto, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Roberto Pini, Istituto di Fisica Applicata "Nello Carrara" (Italy)


Published in SPIE Proceedings Vol. 10494:
Photons Plus Ultrasound: Imaging and Sensing 2018
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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