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Proceedings Paper

Integrated SRS and fluorescence imaging for study of thermogenesis and lipid metabolism in vivo
Author(s): Sicong He; Yitai An; Xuesong Li; Zhenguo Wu; Jianan Y. Qu
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Paper Abstract

In this work, we developed a label-free imaging and spectroscopy method to assess the metabolism and thermogenesis of mouse adipose tissues in vivo. An optical redox ratio based on the endogenous fluorescence of mitochondrial coenzymes was used as a biomarker to determine the metabolic state of adipocytes during thermogenesis. The morphological and functional characteristics of different types of adipocytes were assessed in vivo and their thermogenic activities were monitored in real time with a robust spectroscope system.

Paper Details

Date Published: 23 February 2018
PDF: 6 pages
Proc. SPIE 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII, 104981I (23 February 2018); doi: 10.1117/12.2289659
Show Author Affiliations
Sicong He, Hong Kong Univ. of Science and Technology (Hong Kong, China)
Yitai An, Hong Kong Univ. of Science and Technology (Hong Kong, China)
Xuesong Li, Hong Kong Univ. of Science and Technology (Hong Kong, China)
Zhenguo Wu, Hong Kong Univ. of Science and Technology (Hong Kong, China)
Jianan Y. Qu, Hong Kong Univ. of Science and Technology (Hong Kong, China)


Published in SPIE Proceedings Vol. 10498:
Multiphoton Microscopy in the Biomedical Sciences XVIII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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