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Proceedings Paper

HSA/PSS coated gold nanorods as thermo-triggered drug delivery vehicles for combined cancer photothermal therapy and chemotherapy
Author(s): Ting-Yu Tu; Shu-Jyuan Yang; Chung-Hao Wang; Shin-Yu Lee; Ming-Jium Shieh
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Paper Abstract

Drug delivery systems combined multimodal therapy strategies are very promising in cancer theranostic applications. In this work, a new drug-delivery vehicles based on human serum albumin (HSA)-coated gold nanorods (GNR/PSS/HSA NPs) was developed. The success of coating was verified by transmission electron microscopy (TEM), zeta potential and fourier transform infrared spectroscopy (FTIR). Furthermore, it is demonstrated that doxorubicin (DOX) is successfully loaded among multilayered gold nanorods by the electrostatic and hydrophobic force, and DOX@GNR/PSS/HSA NPs were highly biocompatible and stable in various physiological solutions. The NPs possess strong absorbance in nearinfrared (NIR) region, and high photothermal conversion efficiency for outstanding photothermal therapy applications. A bimodal drug release triggered by proteinase or NIR irradiation has been revealed, resulting in a significant chemotherapeutic effect in tumor sites because of the preferential drug accumulation and triggered release. Importantly, the in vitro and in vivo experiments demonstrated that DOX@GNR/PSS/HSA NPs, which combined photothermal and chemotherapy for cancer therapy, revealing a remarkably superior synergistic anticancer effect over either monotherapy. All these results suggested a considerable potential of DOX@GNR/PSS/HSA NPs nano-platform for antitumor therapy.

Paper Details

Date Published: 12 February 2018
PDF: 18 pages
Proc. SPIE 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, 104760Z (12 February 2018);
Show Author Affiliations
Ting-Yu Tu, National Taiwan Univ. (Taiwan)
Shu-Jyuan Yang, National Taiwan Univ. (Taiwan)
Gene’e Tech Co. Ltd. (Taiwan)
Apius Bio Inc. (Taiwan)
Chung-Hao Wang, Gene’e Tech Co. Ltd. (Taiwan)
Apius Bio Inc. (Taiwan)
Shin-Yu Lee, National Taiwan Univ. (Taiwan)
Ming-Jium Shieh, National Taiwan Univ. (Taiwan)
National Taiwan Univ. Hospital and College of Medicine (Taiwan)

Published in SPIE Proceedings Vol. 10476:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII
David H. Kessel; Tayyaba Hasan, Editor(s)

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