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Proceedings Paper

Imaging guided photo-mediated ultrasound therapy (Conference Presentation)

Paper Abstract

We have developed a safe, noninvasive imaging-guided localized antivascular method, namely photo-mediated ultrasound therapy (PUT), by applying synchronized laser and ultrasound pulses. Through our experimental and theoretical studies, we demonstrate that cavitation plays a key role in PUT. PUT promotes cavitation activity in blood vessels by concurrently applying ultrasound bursts and nanosecond laser pulses. The collapse of cavitation can induce damage to blood vessel endothelial cells, resulting in occlusion of microvessels. This study presents the effect of laser pulse energy, laser pulse length, ultrasound intensity, and synchronization time between laser and ultrasound. We found that, in order to produce controllable blood vessel occlusion, linear oscillation of cavitation (or non-inertial cavitation) might be the key, while strong collapse of cavitation (inertial cavitation) might induce bleeding. Under the guidance an optical coherence tomography (OCT) system, we utilized PUT to remove microvessels in the rabbit choroid. We were able to monitor cavitation activity in real-time in vivo during PUT treatment, and predict treatment outcome. Histology findings confirmed that fibrin clots were developed in the microvessels in the treated region, while no damage was found in the surrounding tissue.

Paper Details

Date Published: 15 March 2018
Proc. SPIE 10492, Optical Interactions with Tissue and Cells XXIX, 1049208 (15 March 2018);
Show Author Affiliations
Haonan Zhang, Tongji Univ. (China)
Univ. of Michigan (United States)
Jia Li, Nanjing Medical Univ. (China)
Univ. of Michigan (United States)
Wei Zhang, Chinese Academy of Medical Sciences (China)
Univ. of Michigan (United States)
Peking Union Medical College (China)
Xinyi Xie, Nanjing Medical Univ. (China)
Univ. of Michigan (United States)
Qian Cheng, Tongji Univ. (China)
Yannis M. Paulus, Univ. of Michigan (United States)
Xinmai Yang, The Univ. of Kansas (United States)
Xueding Wang, Tongji Univ. (China)
Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 10492:
Optical Interactions with Tissue and Cells XXIX
E. Duco Jansen; Hope Thomas Beier, Editor(s)

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