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Proceedings Paper

Imaging guided photo-mediated ultrasound therapy to remove choroidal blood vessels (Conference Presentation)

Paper Abstract

Wet age-related macular degeneration (AMD) is a leading cause of vision loss in the United States. Choroidal neovascularization (CNV), the creation of new blood vessels in the choroid layer of the eye, plays a central role in the pathophysiology of wAMD. Despite advanced anti-VEGF therapy, 20% of patients become legally blind and other 30% suffer significant vision loss after 5 years. Given the significant burden imposed by wAMD on a growing aging population, there is an urgent need for developing new therapeutic techniques to remove microvessels induced by CNV. We developed a safe, noninvasive imaging-guided photo-mediated ultrasound therapy (PUT) technique as a localized antivascular method, and applied it to remove microvessels in the rabbit choroid. This technique promotes cavitation activity in blood vessels by concurrently applying ultrasound bursts and nanosecond laser pulses. The collapse of cavitation can induce damage to blood vessel endothelial cells, resulting in occlusion of microvessels. PUT takes advantages of the high native optical contrast among biological tissues, and has the unique capability to self-target microvessels without causing surrounding damages. Under the guidance of a fundus camera and an optical coherence tomography (OCT) system, our PUT system now has the capability to precisely target the treating area before the treatment procedure (through the fundus camera), and real-time intra-treatment cavitation monitor to evaluate the therapeutic effect (through the OCT system). Additionally, the safety of PUT technique is confirmed by histopathological studies.

Paper Details

Date Published: 14 March 2018
Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104740K (14 March 2018); doi: 10.1117/12.2289004
Show Author Affiliations
Haonan Zhang, Tongji Univ. (China)
Univ. of Michigan (United States)
Jia Li, Nanjing Medical Univ. (China)
Univ. of Michigan (United States)
Zhang Wei, Chinese Academy of Medical Sciences (China)
Univ. of Michigan (United States)
Peking Union Medical College Hospital (China)
Xinyi Xie, Nanjing Medical Univ. (China)
Univ. of Michigan (United States)
Qian Cheng, Tongji Univ. (China)
Yannis M. Paulus, Univ. of Michigan (United States)
Xinmai Yang, The Univ. of Kansas (United States)
Xueding Wang, Tongji Univ. (China)
Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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