Share Email Print

Proceedings Paper

Decay time images of HpD fluorescence for tumor detection in mice
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

A system for time-gated imaging has been used to measure the spatial distribution of the fluorescence decay time in tumor-bearing mice sensitized with Hematoporphyrin Derivative. Mice were injected with five doses of the sensitizer ranging from 0.1 to 10 mg/kg body weight. Several fluorescence images of each mouse were acquired at different delays after the excitation pulses, and a matrix processing algorithm was applied to calculate the average decay time corresponding to each pixel. It was found that, for any drug dose, the decay time of the exogenous fluorescence in the tumor is always significantly longer than in normal tissues. The images created by associating a gray scale to the decay time matrix of each sample allow a reliable and precise detection of the neoplasia, even with a very low dose of the sensitizer.

Paper Details

Date Published: 27 December 1995
PDF: 7 pages
Proc. SPIE 2627, Optical Biopsies, (27 December 1995); doi: 10.1117/12.228883
Show Author Affiliations
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Gianfranco L. Canti, Univ. di Milano (Italy)
Paola Taroni, Politecnico di Milano (Italy)
Gianluca Valentini, Politecnico di Milano (Italy)

Published in SPIE Proceedings Vol. 2627:
Optical Biopsies
Rinaldo Cubeddu; Serge R. Mordon; Katarina Svanberg M.D., Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?