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Proceedings Paper

A bio-inspired design of live cell biosensors
Author(s): A. Marcek Chorvatova; T. Teplicky; Z. Pavlinska; Z. Kronekova; D. Trelova; F. Razga; V. Nemethova; L. Uhelska; I. Lacik; D. Chorvat Jr.
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Paper Abstract

The last decade has witnessed a rapid growth of nanoscale-oriented biosensors that becomes one of the most promising and rapidly growing areas of modern research. Despite significant advancements in conception of such biosensors, most are based at evaluation of molecular, or protein interactions. It is however becoming increasingly evident that functionality of a living system does not reside in genome or in individual proteins, as no real biological functionality is expressed at these levels. Instead, to comprehend the true functioning of a biological system, it is essential to understand the integrative physiological behavior of the complex molecular interactions in their natural environment and precise spatio-temporal topology. In this contribution we therefore present a new concept for creation of biosensors, bio-inspired from true functioning of living cells, while monitoring their endogenous fluorescence, or autofluorescence.

Paper Details

Date Published: 20 February 2018
PDF: 12 pages
Proc. SPIE 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV, 105060R (20 February 2018); doi: 10.1117/12.2288789
Show Author Affiliations
A. Marcek Chorvatova, International Laser Ctr. (Slovakia)
Univ. of SS Cyril and Methodius (Slovakia)
T. Teplicky, International Laser Ctr. (Slovakia)
Univ. of SS Cyril and Methodius (Slovakia)
Z. Pavlinska, International Laser Ctr. (Slovakia)
Univ. of SS Cyril and Methodius (Slovakia)
Z. Kronekova, Polymer Institute SAS (Slovakia)
D. Trelova, Polymer Institute SAS (Slovakia)
F. Razga, Polymer Institute SAS (Slovakia)
V. Nemethova, Polymer Institute SAS (Slovakia)
L. Uhelska, Polymer Institute SAS (Slovakia)
I. Lacik, Polymer Institute SAS (Slovakia)
D. Chorvat Jr., International Laser Ctr. (Slovakia)


Published in SPIE Proceedings Vol. 10506:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV
Alexander N. Cartwright; Dan V. Nicolau; Dror Fixler, Editor(s)

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