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Proceedings Paper

Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography
Author(s): Ratheesh K. Meleppat; Myeong Jin Ju; Pengfei Zhang; Yifan Jian; Suman Manna; Daniel J. Wahl; Marinko V. Sarunic; Edward N. Pugh Jr.; Robert J. Zawadzki
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Paper Abstract

Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality in the mouse retina. The quantitative assessment of the reflectivity of retinal layers of a BALB/c and WT pigmented mice was performed in-vivo using a swept-source optical coherence tomography system. The intensities of backscattered signals from different outer retinal layers were measured and compared.

Paper Details

Date Published: 18 March 2018
PDF: 5 pages
Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104742B (18 March 2018); doi: 10.1117/12.2288739
Show Author Affiliations
Ratheesh K. Meleppat, Univ. of California, Davis (United States)
Myeong Jin Ju, Simon Fraser Univ. (Canada)
Pengfei Zhang, Univ. of California, Davis (United States)
Yifan Jian, Simon Fraser Univ. (Canada)
Suman Manna, Univ. of California, Davis (United States)
Daniel J. Wahl, Simon Fraser Univ. (Canada)
Marinko V. Sarunic, Simon Fraser Univ. (Canada)
Edward N. Pugh Jr., Univ. of California, Davis (United States)
Robert J. Zawadzki, Univ. of California, Davis (United States)

Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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