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Proceedings Paper

Association between background parenchymal enhancement of breast MRI and BIRADS rating change in the subsequent screening
Author(s): Faranak Aghaei; Seyedehnafiseh Mirniaharikandehei; Alan B. Hollingsworth; Rebecca G. Stoug; Melanie Pearce; Hong Liu; Bin Zheng
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Paper Abstract

Although breast magnetic resonance imaging (MRI) has been used as a breast cancer screening modality for high-risk women, its cancer detection yield remains low (i.e., ≤ 3%). Thus, increasing breast MRI screening efficacy and cancer detection yield is an important clinical issue in breast cancer screening. In this study, we investigated association between the background parenchymal enhancement (BPE) of breast MRI and the change of diagnostic (BIRADS) status in the next subsequent breast MRI screening. A dataset with 65 breast MRI screening cases was retrospectively assembled. All cases were rated BIRADS-2 (benign findings). In the subsequent screening, 4 cases were malignant (BIRADS-6), 48 remained BIRADS-2 and 13 were downgraded to negative (BIRADS-1). A computer-aided detection scheme was applied to process images of the first set of breast MRI screening. Total of 33 features were computed including texture feature and global BPE features. Texture features were computed from either a gray-level co-occurrence matrix or a gray level run length matrix. Ten global BPE features were also initially computed from two breast regions and bilateral difference between the left and right breasts. Box-plot based analysis shows positive association between texture features and BIRADS rating levels in the second screening. Furthermore, a logistic regression model was built using optimal features selected by a CFS based feature selection method. Using a leave-one-case-out based cross-validation method, classification yielded an overall 75% accuracy in predicting the improvement (or downgrade) of diagnostic status (to BIRAD-1) in the subsequent breast MRI screening. This study demonstrated potential of developing a new quantitative imaging marker to predict diagnostic status change in the short-term, which may help eliminate a high fraction of unnecessary repeated breast MRI screenings and increase the cancer detection yield.

Paper Details

Date Published: 6 March 2018
PDF: 8 pages
Proc. SPIE 10579, Medical Imaging 2018: Imaging Informatics for Healthcare, Research, and Applications, 105790R (6 March 2018);
Show Author Affiliations
Faranak Aghaei, The Univ. of Oklahoma (United States)
Seyedehnafiseh Mirniaharikandehei, The Univ. of Oklahoma (United States)
Alan B. Hollingsworth, Mercy Women's Ctr. (United States)
Rebecca G. Stoug, Mercy Women's Ctr. (United States)
Melanie Pearce, Mercy Women's Ctr. (United States)
Hong Liu, The Univ. of Oklahoma (United States)
Bin Zheng, The Univ. of Oklahoma (United States)

Published in SPIE Proceedings Vol. 10579:
Medical Imaging 2018: Imaging Informatics for Healthcare, Research, and Applications
Jianguo Zhang; Po-Hao Chen, Editor(s)

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