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Proceedings Paper

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)
Author(s): Chia-Pin Liang; Jing Dong; Timothy N. Ford; Rohith Reddy; Seyed Hamid Hosseiny Darbrazi; Hamid Farrokhi; Matthew Beatty; Kanwarpal Singh; Barry Vuong; Emilie Beaulieu-Ouellet; Catriona N. Grant; Sarah Giddings; Mireille Rosenberg; Norman S. Nishioka M.D.; Guillermo J. Tearney M.D.

Paper Abstract

Tethered capsule endomicroscopy (TCE) is a new method for performing comprehensive microstructural OCT imaging of gastrointestinal (GI) tract in unsedated patients in a well-tolerated and cost-effective manner. These features of TCE bestow it with significant potential to improve the screening, surveillance and management of various upper gastrointestinal diseases. To achieve clinical adoption of this imaging technique, it is important to validate it with co-registered histology, the current diagnostic gold standard. One such method for co-registering OCT images with histology is laser cautery marking, previously demonstrated using a balloon-centering OCT catheter that operates in conjunction with sedated endoscopy. With laser marking, an OCT area of interest is identified on the screen and this target is marked in the patient by exposing adjacent tissue to laser light that is absorbed by water, creating superficial, visible marks on the mucosal surface. Endoscopy can then be performed after the device is removed and biopsies taken from the marks. In this talk, we will present the design of a tethered capsule laser marking device that uses a distal stepper motor to perform high precision (< 0.5 mm accuracy) laser targeting and high quality OCT imaging. Ex vivo animal tissue tests and pilot human clinical studies using this technology will be presented.

Paper Details

Date Published: 14 March 2018
Proc. SPIE 10470, Endoscopic Microscopy XIII, 104700X (14 March 2018);
Show Author Affiliations
Chia-Pin Liang, Harvard Medical School (United States)
Jing Dong, Harvard Medical School (United States)
Timothy N. Ford, Harvard Medical School (United States)
Rohith Reddy, Harvard Medical School (United States)
Seyed Hamid Hosseiny Darbrazi, Harvard Medical School (United States)
Hamid Farrokhi, Harvard Medical School (United States)
Matthew Beatty, Harvard Medical School (United States)
Kanwarpal Singh, Harvard Medical School (United States)
Barry Vuong, Harvard Medical School (United States)
Emilie Beaulieu-Ouellet, Harvard Medical School (United States)
Catriona N. Grant, Harvard Medical School (United States)
Sarah Giddings, Harvard Medical School (United States)
Mireille Rosenberg, Harvard Medical School (United States)
Norman S. Nishioka M.D., Massachusetts General Hospital (United States)
Guillermo J. Tearney M.D., Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 10470:
Endoscopic Microscopy XIII
Guillermo J. Tearney M.D.; Thomas D. Wang; Melissa J. Suter, Editor(s)

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