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Proceedings Paper

The NPe6 fluorescence measurements by using a fluorescence sensing system for skin photosensitivity risk assessment after photodynamic therapy
Author(s): Keishi Ohtani M.D.; Jitsu Usuda; Emiyu Ogawa; Sachio Maehara; Kentaro Imai; Tatsuya Inoue; Masaru Hagiwara; Masatoshi Kakihana; Naohiro Kajiwara; Tatsuo Ohira; Tsunenori Arai; Norihiko Ikeda M.D.
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Paper Abstract

Background: Skin photosensitivity is a major side effect of photodynamic therapy (PDT). It is induced by the photosensitizer remaining in the skin. It is usually rapidly metabolized by the liver, but the pharmacokinetic profile varies widely among individuals. This makes it difficult to predict the incidence of skin photosensitivity. Therefore, we conducted a prospective study to investigate whether the NPe6 fluorescence intensity in skin after NPe6-PDT could be measured safely in human patients using a fluorescence sensing system for judging the risk of skin photosensitivity.
Methods: The NPe6 fluorescence measurements using a constructed fluorescence sensing system at the inside of the arm were acquired prior to and 5 and 10 minutes after NPe6 administration as well as at the time of PDT (4-5 hours after administration), at discharge (2 or 3 days after PDT), and at 1 or 2 weeks after PDT. Participants were interviewed as to whether they had any complications at 2 weeks after PDT.
Results: Nine male patients and one female patient entered this study. All of the measurements of NPe6 fluorescence in the skin could be obtained without any complications. The spectral peak was detected at the time of discharge (2-3 days after administration) in most cases and it decreased at 1 or 2 weeks after PDT.
Conclusions: The fluorescence of NPe6 in the skin could be detected feasibly using the fluorescence sensing system in human patients. Measuring fluorescence intensity in the skin might be useful to predict the incidence of skin photosensitivity after PDT.

Paper Details

Date Published: 12 February 2018
PDF: 6 pages
Proc. SPIE 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, 104760D (12 February 2018);
Show Author Affiliations
Keishi Ohtani M.D., Tokyo Medical Univ. (Japan)
Jitsu Usuda, Nippon Medical School (Japan)
Emiyu Ogawa, Keio Univ. (Japan)
Sachio Maehara, Tokyo Medical Univ. (Japan)
Kentaro Imai, Tokyo Medical Univ. (Japan)
Tatsuya Inoue, Nippon Medical School (Japan)
Masaru Hagiwara, Tokyo Medical Univ. (Japan)
Masatoshi Kakihana, Tokyo Medical Univ. (Japan)
Naohiro Kajiwara, Tokyo Medical Univ. (Japan)
Tatsuo Ohira, Tokyo Medical Univ. (Japan)
Tsunenori Arai, Keio Univ. (Japan)
Norihiko Ikeda M.D., Tokyo Medical Univ. (Japan)

Published in SPIE Proceedings Vol. 10476:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII
David H. Kessel; Tayyaba Hasan, Editor(s)

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