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Proceedings Paper

Long working distance OCT for phonomicrosurgery: preliminary observation of 3D microstructure of ex vivo specimens (Conference Presentation)

Paper Abstract

Optical Coherence Tomography (OCT) is a promising non-invasive in vivo imaging technology visualizing the 3-dimensional microanatomy of retina, skin and vocal fold. In the field of laryngology, OCT probes installed in an existing laryngoscope have been widely studied. However, there are still a number of critical issues to be resolved to develop a successful phonomicrosurgical OCT system including high-resolution, long working distance (≥400 mm) and rapid 3D image reconstruction, etc. Here we introduce a long working distance OCT with 35µm lateral and 13µm axial resolutions. To the best of our knowledge, this is the first OCT with up to 450mm of working distance as well as µm-level resolutions to identify subepithelial tissue structure of vocal fold. The main purpose of this study is to investigate the feasibility and efficacy of the system in ex-vivo microstructure imaging of vocal fold, especially the Reinke’s space. We tested the imaging capability of the system with the freshly excised canine eyeball and larynx samples before proceeding the study with fresh human laryngectomized specimens. The acquired OCT images were then compared with the corresponding H&E stained histological sections. This correlation study allowed the identification of the epithelial layer, lamina propria, subepithelial glandular structures and vessels of the canine and human specimens from both the OCT and the microscope images ensuring solid correspondence between two different types of visual tissue assessment. This OCT system is developed to directly confirm the lesions during phonomicrosurgeries enabling the clinicians to reduce the number of intraoperative biopsies.

Paper Details

Date Published: 14 March 2018
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Proc. SPIE 10469, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018, 1046902 (14 March 2018); doi: 10.1117/12.2287575
Show Author Affiliations
Jin-Choon Lee M.D., Pusan National Univ. Hospital (Korea, Republic of)
Soo-Geun Wang M.D., Pusan National Univ. Hospital (Korea, Republic of)
Wuisuk Sung M.D., Pusan National Univ. Hospital (Korea, Republic of)
Kyung Un Choi M.D., Pusan National Univ. Hospital (Korea, Republic of)
Hong Ki Kim D.D.S., Koh Young Technology (Korea, Republic of)
Sangyoung Kim, Koh Young Technology, Inc. (Korea, Republic of)
Minkyu Kim, Koh Young Technology, Inc. (Korea, Republic of)
Yongchul Park, Koh Young Technology, Inc. (Korea, Republic of)
Chankwon Lee, Koh Young Technology, Inc. (Korea, Republic of)
Jung Hur, Koh Young Technology, Inc. (Korea, Republic of)
Young-Joo Hong, Koh Young Technology, Inc. (Korea, Republic of)
Jeonghoon Choi, Koh Young Technology, Inc. (Korea, Republic of)
Minyoung Hwangbo, Koh Young Technology, Inc. (Korea, Republic of)
Yuri Koh, Koh Young Technology, Inc. (Korea, Republic of)
Soo-keun Kong, Pusan National Univ. Hospital (Korea, Republic of)


Published in SPIE Proceedings Vol. 10469:
Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018
Brian J. F. Wong M.D.; Justus F. Ilgner M.D.; Max J. Witjes M.D., Editor(s)

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