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Proceedings Paper

Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography (Conference Presentation)

Paper Abstract

Adaptive Optics (AO) retinal imaging is revealing microscopic structures of the eye in a non-invasive way. Due to anisoplanatism, conventional AO systems are efficient on small 1°x1° field of view (FoV). We present a lens-based AO scanning laser ophthalmoscope (SLO) set-up with 2 deformable mirrors (DM), providing high-resolution retinal imaging on a 4°x4° FoV, for an eye pupil diameter of 7 mm. The first DM is in a pupil plane and is driven using a Shack-Hartmann (SH). The second DM is conjugated to a plane located 0.7 mm in front of the retina, to correct for aberrations varying within the FoV. Its shape is optimized using sensorless AO technique. The performance of this set-up was characterized in-vivo by measuring the eyes of four healthy volunteers. The obtained image quality was satisfactory and uniform over the entire FoV. Foveal cones could be resolved and no image distortion was detected. Furthermore, a 10°x10° FoV image was acquired at the fovea of one volunteer, by stitching 9 images recorded at different eccentricities. Finally, different layers of the retina were imaged. In addition to the photoreceptors mosaic, small capillaries and nerve fibers were clearly identified. The presented AO-SLO instrument provides high-resolution images of the retina on a relatively large FoV in reasonable time. With 2 DMs, one SH and no guide star, the system stays quite simple. The imaging performance of the set-up was validated on 4 healthy volunteers and we are currently imaging patients with different eye diseases.

Paper Details

Date Published: 14 March 2018
Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104740H (14 March 2018); doi: 10.1117/12.2287120
Show Author Affiliations
Marie Laslandes, Medizinische Univ. Wien (Austria)
Matthias Salas, Medizinische Univ. Wien (Austria)
Andreas Wartak, Medizinische Univ. Wien (Austria)
Christoph K. Hitzenberger, Medizinische Univ. Wien (Austria)
Michael Pircher, Medizinische Univ. Wien (Austria)

Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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