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Proceedings Paper

Integrated metasurface photonics for miniature flow cytometry (Conference Presentation)
Author(s): Niels Verellen; Dries Vercruysse; Veronique Rochus; Bert Du Bois; Alexandra Dusa; Sarp Kerman; Md. Mahmud-Ul-Hasan; Pol Van Dorpe; Xavier Rottenberg; Liesbet Lagae

Paper Abstract

For many applications in life sciences, the biologically relevant information is probed by means of visible light. Many of the critical optical components have, unfortunately, still a large footprint and heavy price tag. Silicon nitride integrated waveguide optics –allowing for complex routing schemes of visible light across a chip– assumes a promi-nent role in the progressing miniaturization of optical devices. However, in order to have the light in the chip interro-gate a distant biological entity, diffraction gratings have to be used to couple light out of the chip. Ideally, all the light from a waveguide would be coupled out into a beam with a predefined polarization, phase, and intensity profile. As such they should be able to produce any functional beam that is typically prepared by free space optical components. For a standard, linear grating an exponential intensity decay is observed along the grating, i.e., more light is coupled out at the start than at the end. Here, we present a specially designed metasurface that is able to deliver highly uniform illumination escaping the photonics chip in a collimated beam at a predesigned angle. Because of its integrated nature, a component like this is highly relevant for the miniaturization of, e.g., flow cytometry applications. We therefore include microfluidic chan-nels on top of the photonics chip and demonstrate the cytometric capabilities with fluorescent polystyrene beads. The opto-fluidic chips are processed in a CMOS pilot line. Our work demonstrates the potential of integrated visible pho-tonics and flat optics for life science applications.

Paper Details

Date Published: 15 March 2018
Proc. SPIE 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV, 105060X (15 March 2018); doi: 10.1117/12.2287116
Show Author Affiliations
Niels Verellen, IMEC (Belgium)
Dries Vercruysse, IMEC (Belgium)
Veronique Rochus, IMEC (Belgium)
Bert Du Bois, IMEC (Belgium)
Alexandra Dusa, IMEC (Belgium)
Sarp Kerman, IMEC (Belgium)
Md. Mahmud-Ul-Hasan, IMEC (Belgium)
Pol Van Dorpe, IMEC (Belgium)
Xavier Rottenberg, IMEC (Belgium)
Liesbet Lagae, IMEC (Belgium)

Published in SPIE Proceedings Vol. 10506:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV
Alexander N. Cartwright; Dan V. Nicolau; Dror Fixler, Editor(s)

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