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Proceedings Paper

Gold nanoparticles for non-invasive cell tracking with CT imaging
Author(s): Rinat Meir; Oshra Betzer; Eran Barnoy; Menachem Motiei; Rachela Popovtzer
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Paper Abstract

Cell-based therapies use living cells with therapeutic traits to treat various diseases. This is a beneficial alternative for diseases that existing medicine cannot cure efficiently. However, inconsistent results in clinical trials are preventing the advancement and implementation of cell-based therapy. In order to explain such results, there is a need to discover the fate of the transplanted cells. To answer this need, we developed a technique for noninvasive in vivo cell tracking, which uses gold nanoparticles as contrast agents for CT imaging. Herein, we investigate the design principles of this technique for intramuscular transplantation of therapeutic cells. Longitudinal studies were performed, demonstrating the ability to track cells over long periods of time. As few as 500 cells could be detected and a way to quantify the number of cells visualized by CT was demonstrated. This cell-tracking technology has the potential to become an essential tool in pre-clinical studies as well as in clinical trials and advance cell therapy.

Paper Details

Date Published: 20 February 2018
PDF: 9 pages
Proc. SPIE 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV, 1050617 (20 February 2018);
Show Author Affiliations
Rinat Meir, Bar-Ilan Univ. (Israel)
Oshra Betzer, Bar-Ilan Univ. (Israel)
Eran Barnoy, Bar-Ilan Univ. (Israel)
Menachem Motiei, Bar-Ilan Univ. (Israel)
Rachela Popovtzer, Bar-Ilan Univ. (Israel)

Published in SPIE Proceedings Vol. 10506:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV
Alexander N. Cartwright; Dan V. Nicolau; Dror Fixler, Editor(s)

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