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Proceedings Paper

Investigation of vascular scattering patterns in retinal and choroidal OCT angiography with a contrast agent (Conference Presentation)
Author(s): Marcel Bernucci; Conrad W. Merkle; Vivek J. Srinivasan

Paper Abstract

Optical Coherence Tomography Angiography (OCTA) has recently emerged for imaging vasculature in clinical ophthalmology. Yet, apparent OCTA image artifacts remain challenging to interpret. Here, contrast-enhanced OCTA is employed in rats to help explain these apparent artifacts. By quantifying enhancement due to an intravascular contrast agent with rheological and scattering properties that are different from red blood cells (RBCs), OCTA image features are ascribed to specific rheological and scattering properties of RBCs. By imaging pigmented and unpigmented rats at a wavelength where scattering dominates image contrast (1300 nm), the impact of melanosome scattering on OCT and OCTA signals is determined.

Paper Details

Date Published: 5 April 2018
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Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 1047404 (5 April 2018); doi: 10.1117/12.2286981
Show Author Affiliations
Marcel Bernucci, Univ. of California, Davis (United States)
Conrad W. Merkle, Univ. of California, Davis (United States)
Vivek J. Srinivasan, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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