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Proceedings Paper

Quantification of amyloid deposits and oxygen extraction fraction in the brain with multispectral optoacoustic imaging in arcAbeta mouse model of Alzheimer's disease
Author(s): Ruiqing Ni; Markus Vaas; Markus Rudin; Jan Klohs
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Paper Abstract

Beta-amyloid (Aβ) deposition and vascular dysfunction are important contributors to the pathogenesis in Alzheimer’s disease (AD). However, the spatio-temporal relationship between an altered oxygen metabolism and Aβ deposition in the brain remains elusive. Here we provide novel in-vivo estimates of brain Aβ load with Aβ-binding probe CRANAD-2 and measures of brain oxygen saturation by using multi-spectral optoacoustic imaging (MSOT) and perfusion imaging with magnetic resonance imaging (MRI) in arcAβ mouse models of AD. We demonstrated a decreased cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) in the cortical region of the arcAβ mice compared to wildtype littermates at 24 months. In addition, we showed proof-of-concept for the detection of cerebral Aβ deposits in brain from arcAβ mice compared to wild-type littermates.

Paper Details

Date Published: 19 February 2018
PDF: 6 pages
Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104941G (19 February 2018); doi: 10.1117/12.2286309
Show Author Affiliations
Ruiqing Ni, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)
Markus Vaas, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)
Markus Rudin, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)
Jan Klohs, Univ. Zürich (Switzerland)
ETH Zurich (Switzerland)


Published in SPIE Proceedings Vol. 10494:
Photons Plus Ultrasound: Imaging and Sensing 2018
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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