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Proceedings Paper

In vivo vascular flow profiling combined with optical tweezers based blood routing
Author(s): Robert Meissner; Wade W. Sugden; Arndt F. Siekmann; Cornelia Denz
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Paper Abstract

In vivo wall shear rate is quantified during zebrafish development using particle image velocimetry for biomedical diagnosis and modeling of artificial vessels. By using brightfield microscopy based high speed video tracking we can resolve single heart-beat cycles of blood flow in both space and time. Maximum blood flow velocities and wall shear rates are presented for zebrafish at two and three days post fertilization. By applying biocompatible optical tweezers as an Optical rail we present rerouting of red blood cells in vivo. With purely light-driven means we are able to compensate the lack of proper red blood cell blood flow in so far unperfused capillaries.

Paper Details

Date Published: 28 July 2017
PDF: 5 pages
Proc. SPIE 10413, Novel Biophotonics Techniques and Applications IV, 104130H (28 July 2017);
Show Author Affiliations
Robert Meissner, Westfälische Wilhelms-Univ. Münster (Germany)
Wade W. Sugden, Max Planck Institute for Molecular Biomedicine (Germany)
Arndt F. Siekmann, Max Planck Institute for Molecular Biomedicine (Germany)
Cornelia Denz, Westfälische Wilhelms-Univ. Münster (Germany)

Published in SPIE Proceedings Vol. 10413:
Novel Biophotonics Techniques and Applications IV
Arjen Amelink, Editor(s)

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