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Proceedings Paper

Delayed luminescence in a multiparameter approach to evaluation and reduction of radiobiological risks
Author(s): Rosaria Grasso; Francesco Paolo Cammarata; Luigi Minafra; Valentina Marchese; Giorgio Russo; Lorenzo Manti; Francesco Musumeci; Agata Scordino
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Paper Abstract

In the framework of the research project ETHICS “Pre-clinical experimental and theoretical studies to improve treatment and protection by charged particles” funded by the National Nuclear Physics Institute, Italy, we studied the phenomenon called delayed luminescence emitted by non-tumorigenic breast epithelial MCF10A cell line after proton irradiation at different doses (0.5, 2, 6, 9 Gy). The aim is to found possible correlations between delayed luminescence and in vitro damaging induced by ion irradiation. The first results of this research show that the delayed luminescence kinetics is proton dose dependent. An interesting correlation between delayed luminescence and clonogenic potential was observed.

Paper Details

Date Published: 28 July 2017
PDF: 8 pages
Proc. SPIE 10413, Novel Biophotonics Techniques and Applications IV, 104130L (28 July 2017); doi: 10.1117/12.2285851
Show Author Affiliations
Rosaria Grasso, Univ. degli Studi di Catania (Italy)
Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud (Italy)
Francesco Paolo Cammarata, Institute of Molecular Bioimaging and Physiology, CNR (Italy)
Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud (Italy)
Luigi Minafra, Institute of Molecular Bioimaging and Physiology, CNR (Italy)
Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud (Italy)
Valentina Marchese, Institute of Molecular Bioimaging and Physiology, CNR (Italy)
Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud (Italy)
Giorgio Russo, Institute of Molecular Bioimaging and Physiology, CNR (Italy)
Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud (Italy)
Lorenzo Manti, Univ. degli Studi di Napoli Federico II (Italy)
Francesco Musumeci, Univ. degli Studi di Catania (Italy)
Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud (Italy)
Agata Scordino, Univ. degli Studi di Catania (Italy)
Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud (Italy)


Published in SPIE Proceedings Vol. 10413:
Novel Biophotonics Techniques and Applications IV
Arjen Amelink, Editor(s)

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