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Proceedings Paper

RGD peptide-targeted polyethylenimine-entrapped gold nanoparticles for targeted CT imaging of an orthotopic model of human hepatocellular carcinoma
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Paper Abstract

We report the synthesis and characterization of arginine-glycine-aspartic acid (RGD) peptide-targeted polyethylenimine (PEI)-entrapped gold nanoparticles (RGD-Au PENPs) for targeted CT imaging of hepatic carcinomas in situ. In this work, PEI sequentially modified with polyethylene glycol (PEG), and RGD linked-PEG was used as a nanoplatform to prepare AuNPs, followed by complete acetylation of PEI surface amines. We showed that the designed RGD-Au PENPs were colloidally stable and biocompatible in the given concentration range, and could be specifically taken up by αvβ3 integrin-overexpressing liver cancer cells in vitro. Furthermore, in vivo CT imaging results revealed that the particles displayed a great contrast enhancement of hepatic carcinomas region, and could target to hepatic carcinomas region in situ. With the proven biodistribution and histological examinations in vivo, the synthesized RGD-Au PENPs show a great formulation to be used as a contrast agent for targeted CT imaging of different αvβ3 integrin receptoroverexpressing tumors.

Paper Details

Date Published: 19 February 2018
PDF: 8 pages
Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 104950O (19 February 2018);
Show Author Affiliations
Benqing Zhou, Shenzhen Univ. (China)
Univ. of Central Oklahoma (United States)
Meng Wang, Shenzhen Univ. (China)
Univ. of Central Oklahoma (United States)
Feifan Zhou, Shenzhen Univ. (China)
Univ. of Central Oklahoma (United States)
Jun Song, Shenzhen Univ. (China)
Junle Qu II, Shenzhen Univ. (China)
Wei R. Chen, Shenzhen Univ. (China)
Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 10495:
Biophotonics and Immune Responses XIII
Wei R. Chen, Editor(s)

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