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Proceedings Paper

Enabling multi-site intra spinal canal dosimetry of transcutaneous photobiomodulation therapy on cadaver dogs using a custom designed, flexible, 9-channel photo-diode probe (Conference Presentation)
Author(s): Daqing Piao; Lara Sypniewski D.V.M.; Christian Bailey; Danielle Dugat D.V.M.; Shaghayegh Aslanzadeh; Daniel Burba; Luis H. De Taboada

Paper Abstract

Transcutaneous photobiomodulation of the spinal cord in rodent models has shown therapeutic effects to spinal cord injury. For translation to human medicine; however, it remains unknown if a therapeutic dose can reach the spinal cord with a non-invasive treatment protocol that does not cause collateral tissue damage. Our previous pilot test on a cadaver dog using a single photo-diode-sensor demonstrated that the transcutaneous transmission of 980nm light to the spinal canal through the shallowest section of the vertebrae was comparable to the transcranial transmission. The use of a single sensor to measure at multiple positions along the spinal canal challenged correlations of the results, due to variations of sensor-tissue geometry after repositioning the sensor within the spinal canal and closing the tissue for light transmission. To identify a potential transmission window for delivering an effective photobiomodulation therapy dose to the spinal cord, and to evaluate inter-subject variations, it is essential to maintain consistency in intra-spinal measurements at multiple positions for any one subject and across multiple subjects. We developed a flexible multi-channel photo-detector-array specifically for measuring the transmission of light to the spinal canal at multiple sites under fixed surface irradiation. The probe, with a 1/4" stem, contains 9 photo-diodes spaced 1cm apart allowing measurement over an 8cm length. Multi-site dosimetry at 980nm was tested in one cadaver dog at a fixed surface (shaved skin) irradiance of 3.18 W/cm2 by deploying the applicator-probe in the spinal canal after hemilaminectomy, and will be repeated in a total of six dogs.

Paper Details

Date Published: 14 March 2018
PDF
Proc. SPIE 10477, Mechanisms of Photobiomodulation Therapy XIII, 1047706 (14 March 2018); doi: 10.1117/12.2284800
Show Author Affiliations
Daqing Piao, Oklahoma State Univ. (United States)
Lara Sypniewski D.V.M., Oklahoma State Univ. (United States)
Christian Bailey, Oklahoma State Univ. (United States)
Danielle Dugat D.V.M., Oklahoma State Univ. (United States)
Shaghayegh Aslanzadeh, Oklahoma State Univ. (United States)
Daniel Burba, Oklahoma State Univ. (United States)
Luis H. De Taboada, LiteCure, LLC (United States)


Published in SPIE Proceedings Vol. 10477:
Mechanisms of Photobiomodulation Therapy XIII
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

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