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Proceedings Paper

A quantitative reconstruction software suite for SPECT imaging
Author(s): Mauro Namías; Robert Jeraj
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Paper Abstract

Quantitative Single Photon Emission Tomography (SPECT) imaging allows for measurement of activity concentrations of a given radiotracer in vivo. Although SPECT has usually been perceived as non-quantitative by the medical community, the introduction of accurate CT based attenuation correction and scatter correction from hybrid SPECT/CT scanners has enabled SPECT systems to be as quantitative as Positron Emission Tomography (PET) systems. We implemented a software suite to reconstruct quantitative SPECT images from hybrid or dedicated SPECT systems with a separate CT scanner. Attenuation, scatter and collimator response corrections were included in an Ordered Subset Expectation Maximization (OSEM) algorithm. A novel scatter fraction estimation technique was introduced. The SPECT/CT system was calibrated with a cylindrical phantom and quantitative accuracy was assessed with an anthropomorphic phantom and a NEMA/IEC image quality phantom. Accurate activity measurements were achieved at an organ level. This software suite helps increasing quantitative accuracy of SPECT scanners.

Paper Details

Date Published: 17 November 2017
PDF: 9 pages
Proc. SPIE 10572, 13th International Conference on Medical Information Processing and Analysis, 105721K (17 November 2017);
Show Author Affiliations
Mauro Namías, Fundación Ctr. Diagnóstico Nuclear (Argentina)
Robert Jeraj, Univ. of Wisconsin Carbone Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 10572:
13th International Conference on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva; Juan David García, Editor(s)

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