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Proceedings Paper

A technique for measuring oxygen saturation in biological tissues based on diffuse optical spectroscopy
Author(s): Mikhail Kleshnin; Anna Orlova; Mikhail Kirillin; German Golubiatnikov; Ilya Turchin
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Paper Abstract

A new approach to optical measuring blood oxygen saturation was developed and implemented. This technique is based on an original three-stage algorithm for reconstructing the relative concentration of biological chromophores (hemoglobin, water, lipids) from the measured spectra of diffusely scattered light at different distances from the probing radiation source. The numerical experiments and approbation of the proposed technique on a biological phantom have shown the high reconstruction accuracy and the possibility of correct calculation of hemoglobin oxygenation in the presence of additive noise and calibration errors. The obtained results of animal studies have agreed with the previously published results of other research groups and demonstrated the possibility to apply the developed technique to monitor oxygen saturation in tumor tissue.

Paper Details

Date Published: 28 July 2017
PDF: 7 pages
Proc. SPIE 10412, Diffuse Optical Spectroscopy and Imaging VI, 1041212 (28 July 2017); doi: 10.1117/12.2284378
Show Author Affiliations
Mikhail Kleshnin, Institute of Applied Physics (Russian Federation)
Anna Orlova, Institute of Applied Physics (Russian Federation)
Mikhail Kirillin, Institute of Applied Physics (Russian Federation)
German Golubiatnikov, Institute of Applied Physics (Russian Federation)
Ilya Turchin, Institute of Applied Physics (Russian Federation)


Published in SPIE Proceedings Vol. 10412:
Diffuse Optical Spectroscopy and Imaging VI
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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