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Proceedings Paper

In-vivo monitoring of oxygen saturation in murine carcinoma during PDT by diode laser light diffuse reflectance
Author(s): Vladimir V. Kholin; Oksana M. Chepurna; Irina O. Shton; Valerii S. Voytsehovich; Sergii V. Pavlov; Natalia I. Zabolotna; Ryszard Romaniuk; Waldemar Wójcik; Yedilkhan Amirgaliyev; Vladimir Kovalev
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Paper Abstract

In the paper we explored the possibility of monitoring oxygenation of the tumor tissue through the registration of light diffuse reflectance. This method can also be helpful for assessment the effectiveness of PDT, defining the level of vascular damage and the degree of the tumor oxygenation. We also propose the modification of PDT procedure by using a modulated laser that enables to better maintain the necessary parameters for the PS activation and oxygen generation in irradiated tissues simultaneously allowing to reduce the light dose required for tumor treatment.

Paper Details

Date Published: 7 August 2017
PDF: 6 pages
Proc. SPIE 10445, Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017, 104453N (7 August 2017); doi: 10.1117/12.2280980
Show Author Affiliations
Vladimir V. Kholin, PSME “Fotonika Plus” (Ukraine)
Oksana M. Chepurna, PSME “Fotonika Plus” (Ukraine)
Irina O. Shton, Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (Ukraine)
Valerii S. Voytsehovich, Institute of Physics (Ukraine)
Sergii V. Pavlov, Vinnytsia National Technical Univ. (Ukraine)
Natalia I. Zabolotna, Vinnytsia National Technical Univ. (Ukraine)
Ryszard Romaniuk, Warsaw Univ. of Technology (Poland)
Waldemar Wójcik, Lublin Univ. of Technology (Poland)
Yedilkhan Amirgaliyev, Institute of Information and Computational Technologies (Kazakhstan)
Vladimir Kovalev, Institute of Radio-engineering and Electronics (Russian Federation)

Published in SPIE Proceedings Vol. 10445:
Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017
Ryszard S. Romaniuk; Maciej Linczuk, Editor(s)

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