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Proceedings Paper

Quantitative compressional OCE: obviating pitfalls in using pre-calibrated compliant layers and some other practical obstacles
Author(s): Alexandr A. Sovetsky; Alexander L. Matveyev; Lev A. Matveev; Ekaterina V. Gubarkova; Marina A. Sirotkina; Grigory V. Gelikonov; Elena V. Zagaynova; Natalia D. Gladkova; Alex Vitkin; Vladimir Yu. Zaitsev
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Paper Abstract

In this report we discuss some practical obstacles/pitfalls arising in realization of quantitative compressional OCE, as well as discuss possible ways of their resolution. More specifically we consider (i) complications in quantification of the Young modulus of tissues related to influence of partial adhesion between the OCT probe and pre-calibrated reference layers - "compliant sensors", (ii) distorting influence of surface curvature/corrugation on strain distribution in the tissue bulk, (iii) ways of enhancement of effective SNR in OCT-based strain mapping without periodic averaging, and (iv) potentially significant influence of nonlinearity of the elastic response of biological tissues on quantification of their stiffness.

Paper Details

Date Published: 10 August 2018
PDF: 5 pages
Proc. SPIE 10831, Seventh International Conference on Lasers in Medicine, 108310K (10 August 2018);
Show Author Affiliations
Alexandr A. Sovetsky, Institute of Applied Physics (Russian Federation)
Alexander L. Matveyev, Institute of Applied Physics (Russian Federation)
Nizhny Novgorod State Medical Academy (Russian Federation)
Lev A. Matveev, Institute of Applied Physics (Russian Federation)
Nizhny Novgorod State Medical Academy (Russian Federation)
Ekaterina V. Gubarkova, Nizhny Novgorod State Medical Academy (Russian Federation)
Marina A. Sirotkina, Nizhny Novgorod State Medical Academy (Russian Federation)
Grigory V. Gelikonov, Institute of Applied Physics (Russian Federation)
Nizhny Novgorod State Medical Academy (Russian Federation)
Elena V. Zagaynova, Nizhny Novgorod State Medical Academy (Russian Federation)
Natalia D. Gladkova, Nizhny Novgorod State Medical Academy (Russian Federation)
Alex Vitkin, Nizhny Novgorod State Medical Academy (Russian Federation)
Univ. of Toronto and Univ. Health Network (Canada)
Vladimir Yu. Zaitsev, Institute of Applied Physics (Russian Federation)
Nizhny Novgorod State Medical Academy (Russian Federation)


Published in SPIE Proceedings Vol. 10831:
Seventh International Conference on Lasers in Medicine
Carmen Todea M.D.; Adrian Podoleanu; Virgil-Florin Duma, Editor(s)

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