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Proceedings Paper

Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography
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Paper Abstract

Fetal Alcohol Syndrome (FAS) refers to the broad spectrum of developmental and behavioral effects caused due to prenatal alcohol exposure (PAE).
Wide range of abnormalities vary depending on the amount of alcohol consumed and the period of consumption during gestation.
PAE during early stages of pregnancy is very common. However a large number of women continue to consume alcohol even during the second trimester, a critical period for fetal neurogenesis and angiogenesis.
Optical coherence tomography (OCT) has shown to be extremely useful in embryonic imaging.
Our previous work showed that OCT is capable of quantitative assessment of ventriculomegaly caused by maternal alcohol consumption.
Although structural changes and changes in blood flow in the fetal brain after maternal alcohol consumption have been studied, acute vasculature changes are not well documented.
Speckle variance OCT (SVOCT), is a functional extension of OCT that has been used to study vasculature development in embryos.
We use SVOCT, to detect vasculature changes in the embryonic brain in utero, minutes after maternal alcohol consumption.

Paper Details

Date Published: 29 April 2017
PDF: 1 pages
Proc. SPIE 10340, International Conference on Biophotonics V, 103401G (29 April 2017); doi: 10.1117/12.2277143
Show Author Affiliations
Raksha Raghunathan, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Rajesh C. Miranda, Texas A&M Health Science Ctr. (United States)
Kirill V. Larin, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 10340:
International Conference on Biophotonics V
David D. Sampson; Dennis L. Matthews; Jürgen Popp; Halina Rubinsztein-Dunlop; Brian C. Wilson, Editor(s)

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