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Proceedings Paper

Magnetoresistive biosensors for quantitative proteomics
Author(s): Xiahan Zhou; Chih-Cheng Huang; Drew A. Hall
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Paper Abstract

Quantitative proteomics, as a developing method for study of proteins and identification of diseases, reveals more comprehensive and accurate information of an organism than traditional genomics. A variety of platforms, such as mass spectrometry, optical sensors, electrochemical sensors, magnetic sensors, etc., have been developed for detecting proteins quantitatively. The sandwich immunoassay is widely used as a labeled detection method due to its high specificity and flexibility allowing multiple different types of labels. While optical sensors use enzyme and fluorophore labels to detect proteins with high sensitivity, they often suffer from high background signal and challenges in miniaturization. Magnetic biosensors, including nuclear magnetic resonance sensors, oscillator-based sensors, Hall-effect sensors, and magnetoresistive sensors, use the specific binding events between magnetic nanoparticles (MNPs) and target proteins to measure the analyte concentration. Compared with other biosensing techniques, magnetic sensors take advantage of the intrinsic lack of magnetic signatures in biological samples to achieve high sensitivity and high specificity, and are compatible with semiconductor-based fabrication process to have low-cost and small-size for point-of-care (POC) applications. Although still in the development stage, magnetic biosensing is a promising technique for in-home testing and portable disease monitoring.

Paper Details

Date Published: 29 August 2017
PDF: 11 pages
Proc. SPIE 10352, Biosensing and Nanomedicine X, 103520F (29 August 2017); doi: 10.1117/12.2276933
Show Author Affiliations
Xiahan Zhou, Univ. of California, San Diego (United States)
Chih-Cheng Huang, Univ. of California, San Diego (United States)
Drew A. Hall, Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 10352:
Biosensing and Nanomedicine X
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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