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Proceedings Paper

Multi-capillary based optical sensors for highly sensitive protein detection
Author(s): Yasuhira Okuyama; Takashi Katagiri; Yuji Matsuura
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Paper Abstract

A fluorescence measuring method based on glass multi-capillary for detecting trace amounts of proteins is proposed. It promises enhancement of sensitivity due to effects of the adsorption area expansion and the longitudinal excitation. The sensitivity behavior of this method was investigated by using biotin-streptavidin binding. According to experimental examinations, it was found that the sensitivity was improved by a factor of 70 from common glass wells. We also confirmed our measuring system could detect 1 pg/mL of streptavidin. These results suggest that multi-capillary has a potential as a high-sensitive biosensor.

Paper Details

Date Published: 18 April 2017
PDF: 2 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511W (18 April 2017); doi: 10.1117/12.2275021
Show Author Affiliations
Yasuhira Okuyama, Tohoku Univ. (Japan)
Takashi Katagiri, Tohoku Univ. (Japan)
Yuji Matsuura, Tohoku Univ. (Japan)

Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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