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Proceedings Paper

Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy
Author(s): Yasumitsu Ishimaru; Yusuke Oshima; Yuuki Imai; Tadahiro Iimura; Sota Takanezawa; Kazunori Hino; Hiromasa Miura
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Paper Abstract

To evaluate the bone quality in the osteoporosis, we generated sciatic nerve resection (NX) mice as an osteoporosis model and analyzed by Raman spectroscopy. Raman spectra were measured in anterior cortical surface of the proximal tibia at 5 points in each bone. After that, the samples were fixed with 70% ethanol. We then performed DXA and μCT measurement. Raman peak intensity ratios were significantly different between NX and Control. Those changes in the Raman peak intensity ratios may reflect loss of bone quality in the osteoporosis model. Raman spectroscopy is a promising technique for measuring the bone quality and bone strength.

Paper Details

Date Published: 18 April 2017
PDF: 3 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511D (18 April 2017); doi: 10.1117/12.2274980
Show Author Affiliations
Yasumitsu Ishimaru, Ehime Univ. (Japan)
Yusuke Oshima, Ehime Univ. (Japan)
Yuuki Imai, Ehime Univ. (Japan)
Tadahiro Iimura, Ehime Univ. (Japan)
Sota Takanezawa, Ehime Univ. (Japan)
Kazunori Hino, Ehime Univ. (Japan)
Hiromasa Miura, Ehime Univ. (Japan)

Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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