Share Email Print

Proceedings Paper

Light propagation analysis for fluorescence measurements of a molecular probe in the brain
Author(s): Kota Asai; Takuya Togashi; Eiji Okada
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.

Paper Details

Date Published: 18 April 2017
PDF: 2 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511S (18 April 2017); doi: 10.1117/12.2274896
Show Author Affiliations
Kota Asai, Keio Univ. (Japan)
Takuya Togashi, Keio Univ. (Japan)
Eiji Okada, Keio Univ. (Japan)

Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?