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Proceedings Paper

Probing mechanobiology with laser-induced shockwaves
Author(s): Christopher Carmona; Daryl C. Preece; Veronica Gomez-Godinez; Linda Z. Shi; Michael W. Berns
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Paper Abstract

Traumatic Brain Injury (TBI) occurs when an external force injures the brain. While clinical outcomes of TBI can vary widely in severity, few mechanisms of neurodegeneration following TBI have been identified for treatment. We propose a model for studying TBI using laser-induced shockwaves (LISs). An optical system was developed that allows single cells to be studied in response to LISs. Our system utilizes an optically-coupled force measurement component that allows for the visualization of shockwave dynamics. Here, the force measurement system is characterized by imaging stages over the period of violent expansion and collapse of microbubbles responsible for shockwave generation.

Paper Details

Date Published: 25 August 2017
PDF: 5 pages
Proc. SPIE 10347, Optical Trapping and Optical Micromanipulation XIV, 103470D (25 August 2017); doi: 10.1117/12.2274563
Show Author Affiliations
Christopher Carmona, Univ. of California, San Diego (United States)
Daryl C. Preece, Univ. of California, San Diego (United States)
Veronica Gomez-Godinez, Univ. of California, San Diego (United States)
Linda Z. Shi, Univ. of California, San Diego (United States)
Michael W. Berns, Beckman Laser Institute and Medical Clinic (United States)

Published in SPIE Proceedings Vol. 10347:
Optical Trapping and Optical Micromanipulation XIV
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

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