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Proceedings Paper

A multi-layer MRI description of Parkinson's disease
Author(s): M. La Rocca; N. Amoroso; E. Lella; R. Bellotti; S. Tangaro
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Paper Abstract

Magnetic resonance imaging (MRI) along with complex network is currently one of the most widely adopted techniques for detection of structural changes in neurological diseases, such as Parkinson's Disease (PD). In this paper, we present a digital image processing study, within the multi-layer network framework, combining more classifiers to evaluate the informative power of the MRI features, for the discrimination of normal controls (NC) and PD subjects. We define a network for each MRI scan; the nodes are the sub-volumes (patches) the images are divided into and the links are defined using the Pearson's pairwise correlation between patches. We obtain a multi-layer network whose important network features, obtained with different feature selection methods, are used to feed a supervised multi-level random forest classifier which exploits this base of knowledge for accurate classification. Method evaluation has been carried out using T1 MRI scans of 354 individuals, including 177 PD subjects and 177 NC from the Parkinson's Progression Markers Initiative (PPMI) database. The experimental results demonstrate that the features obtained from multiplex networks are able to accurately describe PD patterns. Besides, also if a privileged scale for studying PD disease exists, exploring the informative content of more scales leads to a significant improvement of the performances in the discrimination between disease and healthy subjects. In particular, this method gives a comprehensive overview of brain regions statistically affected by the disease, an additional value to the presented study.

Paper Details

Date Published: 19 September 2017
PDF: 9 pages
Proc. SPIE 10396, Applications of Digital Image Processing XL, 1039618 (19 September 2017); doi: 10.1117/12.2274169
Show Author Affiliations
M. La Rocca, Univ. degli Studi di Bari (Italy)
Istituto Nazionale di Fisica Nucleare (Italy)
N. Amoroso, Univ. degli Studi di Bari (Italy)
Istituto Nazionale di Fisica Nucleare (Italy)
E. Lella, Univ. degli Studi di Bari (Italy)
Istituto Nazionale di Fisica Nucleare (Italy)
R. Bellotti, Univ. degli Studi di Bari (Italy)
Istituto Nazionale di Fisica Nucleare (Italy)
S. Tangaro, Istituto Nazionale di Fisica Nucleare (Italy)

Published in SPIE Proceedings Vol. 10396:
Applications of Digital Image Processing XL
Andrew G. Tescher, Editor(s)

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