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Proceedings Paper

Handheld highly selective plasmonic chem/biosensor using engineered binding proteins for extreme conformational changes
Author(s): Derek J. Kosciolek; Ajay Sonar; Lori A. Lepak; Peter Schnatz; Igor Bendoym; Mia C. Brown; Ronald L. Koder; David T. Crouse
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Paper Abstract

In this project we develop a handheld, portable, highly selective and sensitive chem/biosensor that has potential applications in both airborne and water-based environmental sensing. The device relies on a plasmonic chip of subwavelength-scale periodic gold rods engineered to resonate in the near infrared. The chip is functionalized with a novel class of proteins that exhibit large conformational changes upon binding to a specific target analyte. The subsequent change in local refractive index near the surface of the gold is one to two orders of magnitude greater than current conventional methods, which produces a readily measurable 5 to 10 percent difference in light transmission. This allows us to forgo traditional, bulky tabletop setups in favor of a compact form factor. Using commercially available optics to construct a transmission-based optical train, measured changes in bulk refractive index are presented here. While synthesis of binding protein efforts are focused on heme as analyte for proof of concept validation, the functionalized protein can be engineered to pair with a wide variety of analytes with minimal alterations to the plasmonic chip or device design. Such flexibility allows for this device to potentially meet the needs of first responders and health care professionals in a multitude of scenarios.

Paper Details

Date Published: 25 August 2017
PDF: 10 pages
Proc. SPIE 10346, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XV, 103462B (25 August 2017); doi: 10.1117/12.2273207
Show Author Affiliations
Derek J. Kosciolek, Clarkson Univ. (United States)
Ajay Sonar, Clarkson Univ. (United States)
Lori A. Lepak, Phoebus Optoelectronics, LLC (United States)
Peter Schnatz, The City College of New York (United States)
Igor Bendoym, Phoebus Optoelectronics, LLC (United States)
Mia C. Brown, The City College of New York (United States)
Ronald L. Koder, The City College of New York (United States)
David T. Crouse, Clarkson Univ. (United States)
Phoebus Optoelectronics, LLC (United States)

Published in SPIE Proceedings Vol. 10346:
Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XV
Din Ping Tsai; Takuo Tanaka, Editor(s)

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